The mission of the LBI.HF is to improve individualized management of patients at risk for or with symptomatic heart failure. The focus of the LBI.HF will be on earlier detection and cause-and stage specific targeted therapy prior to progressive deterioration, thereby also reducing the socio-economic burden of the disease. For this purpose, the LBI.HF will advance the pathophysiological and mechanistic understanding of disease initiation and progression, and develop new diagnostic and therapeutic strategies. Following clinical validation, new LBI.HF-derived biomarkers and therapeutic concepts of disease progression will be integrated into innovative eHealth solutions and tested in a clinical telemedicine-based pilot heart failure management program.